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Jennifer Doudna: CRISPR Basics

Innovative Genomics Institute – IGI

Innovative Genomics Institute – IGI

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373,848 views • Nov 4, 2017

Jennifer Doudna (University of California, Berkeley) explains the basics of CRISPR immunity, Cas9 mechanics, and anti-CRISPRs. [2017 CRISPR Workshop] ...more

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Chapters

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Intro

0:00

CRISPRs: Hallmarks of acquired immunity in bacteria

1:08

Cas9: RNA-guided DNA cutter

13:59

Mechanism of DNA recognition?

15:08

Morph to modeled docked state of HNH

18:29

Catalytic domain rotation activates Cas9

22:18

Single-molecule FRET detects Cas9 conformational states

24:18

Cas9 detects RNA-DNA hybridization

25:36

A conformational checkpoint for Cas9

27:30

Cas9 HNH domain needed for Acrlici binding

33:34

RNA-guided genome regulation

36:12

What about human germline editing?

40:14

Sync to video time

Description

Jennifer Doudna: CRISPR Basics

6.8KLikes

373,848Views

2017Nov 4

Jennifer Doudna (University of California, Berkeley) explains the basics of CRISPR immunity, Cas9 mechanics, and anti-CRISPRs. [2017 CRISPR Workshop]

Chapters

View all

Intro

0:00

CRISPRs: Hallmarks of acquired immunity in bacteria

1:08

Cas9: RNA-guided DNA cutter

13:59

Mechanism of DNA recognition?

15:08

Transcript

Follow along using the transcript.

Show transcript

Innovative Genomics Institute – IGI

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